194 papers
Infectious diseases represent one of the most dynamic frontiers in global health, covering everything from seasonal flu outbreaks to emerging viral threats that cross borders. This field focuses on how pathogens spread, how our immune systems respond, and the strategies scientists use to stop infections before they become epidemics. Because the science moves fast, waiting for traditional publication often means missing critical insights that could save lives.
At Gist.Science, we process every new preprint in this category directly from medRxiv to ensure you see the latest findings the moment they appear. Our team transforms these raw studies into both accessible plain-language explanations and detailed technical summaries, bridging the gap between complex research and public understanding. Below are the latest papers in infectious diseases, updated daily with fresh insights from the global research community.
By integrating epidemiological surveillance with parasite genomics, this study reveals that malaria in low-transmission southwestern Uganda is predominantly driven by imported infections in Maziba and Muko, whereas Kamwezi experiences sustained local transmission, highlighting the need for tailored interventions based on travel history and genetic data.
This study comparing Truenat MTB Plus and Xpert MTB/RIF Ultra in India found that while Xpert Ultra offers superior diagnostic accuracy and lower indeterminate rates, Truenat provides a cost-effective and operationally feasible alternative for decentralized testing, supporting a tiered approach to expand tuberculosis diagnosis.
This study demonstrates that increasing centrifugal force to 6,000 x g during pre-analytical processing significantly enhances the sensitivity of Ziehl-Neelsen smear microscopy for detecting *Mycobacterium tuberculosis* in clinical sputum samples, thereby reducing false-negative results in routine tuberculosis diagnosis.
This study demonstrates that novel culture-free targeted (tNGS) and direct whole-genome sequencing (dWGS) assays offer sensitive, specific, and high-resolution drug resistance profiling and genotyping for *Mycobacterium tuberculosis* directly from clinical sputum samples, with tNGS showing superior performance at low bacillary loads and dWGS enabling comprehensive transmission analysis.